kewlkat
City
Posts: 242 
Joined: November 2013
Location: IL
Stats: 216/183.5/143 (9/21 - Up 6.5 lbs)
Plan: NK
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Post by kewlkat on Nov 2, 2013 11:07:53 GMT -6
When I have medical issues, I usually research the internet to see if I can find answers or if I can find help. So when I decided to give NK a try I of course had researched it first. I thought maybe you all might be interested in reading some of the rings I find as you also have embraced NK for your own reasons. I found this paper, full text, from the UK. This is an interventional cardiology specialist's assessment regarding saturated fat. Saturated fat is not the major issue, Let’s bust the myth of its role in heart diseaseBMJ 2013;347:f6340 doi: 10.1136/bmj.f6340 (Published 22 October 2013)SNIPPET - The mantra that saturated fat must be removed to reduce the risk of cardiovascular disease Has dominated dietary advice and guidelines for almost four decades. Yet scientific evidence shows that this advice has, paradoxically, increased our cardiovascular risks. Furthermore, the government’s obsession with levels of total cholesterol, which has led to the overmedication of millions of people with statins, has diverted our attention from the more egregious risk factor of atherogenic dyslipidaemia. |
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kewlkat
City
Posts: 242
Joined: November 2013
Location: IL
Stats: 216/183.5/143 (9/21 - Up 6.5 lbs)
Plan: NK
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Post by kewlkat on Nov 2, 2013 11:11:20 GMT -6
Well, apparently the full article is now no longer available for free. I think I do have it downloaded but have no place to upload to and suppose it would be a copyright infringement......Sorry.
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kewlkat
City
Posts: 242
Joined: November 2013
Location: IL
Stats: 216/183.5/143 (9/21 - Up 6.5 lbs)
Plan: NK
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Post by kewlkat on Nov 2, 2013 11:44:19 GMT -6
I can't find a copy on my PC of my original posting but do have this one. Results: During 5–23 y of follow-up of 347,747 subjects, 11,006 developed CHD or stroke. Intake of saturated fat was not associated with an increased risk of CHD, stroke, or CVD. The pooled relative risk estimates that compared extreme quantiles of saturated fat intake were 1.07 (95% CI: 0.96, 1.19; P = 0.22) for CHD, 0.81 (95% CI: 0.62, 1.05; P = 0.11) for stroke, and 1.00 (95% CI: 0.89, 1.11; P = 0.95) for CVD. Consideration of age, sex, and study quality did not change the results. Conclusions: A meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that
dietary saturated fat is associated with an increased risk of CHD
or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat. Am J Clin Nutr doi: 10.3945/ajcn.2009.27725. PROMISE, full text here: Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
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Post by reddarin on Nov 2, 2013 20:18:39 GMT -6
When I have medical issues, I usually research the internet to see if I can find answers or if I can find help. So when I decided to give NK a try I of course had researched it first. I thought maybe you all might be interested in reading some of the things I find as you also have embraced NK for your own reasons. It is always good to have lots of supporting information, thanks kewlkat  How did you become aware of NK? I found it through another forum where a lady was trying to follow the example set by Jimmy Moore and the Performance book. I had the A&S book so I implemented that version and fleshed it out with podcasts and applicable LC information. |
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exotec
Village
Posts: 12
Joined: June 2014
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Post by exotec on Jun 30, 2014 20:19:32 GMT -6
Interesting article. I don't know why the cholesterol battles interest me so much. I don't have heart disease. But the mythinformation being promulgated around just drives me crazy!
I was able to get to the article without problem. I didn't see any notations about copying it for informational purposes. I think most things internet are available for personal use. Since we're not getting any financial or professional gain from it, and only using it for information, I don't think reposting it here should infringe upon any legal rights. Anyway, the link to the source is at the beginning of this thread, and the location of the published version is just below the title here. They're cited!
Here's the text of the article:
Saturated Fat Is Not The Major Issue
BMJ 2013; 347 doi: dx.doi.org/10.1136/bmj.f6340 (Published 22 October 2013)Cite this as: BMJ 2013;347:f6340
Scientists universally accept that trans fats—found in many fast foods, bakery products, and margarines—increase the risk of cardiovascular disease through inflammatory processes.1 But “saturated fat” is another story. The mantra that saturated fat must be removed to reduce the risk of cardiovascular disease has dominated dietary advice and guidelines for almost four decades.
Yet scientific evidence shows that this advice has, paradoxically, increased our cardiovascular risks. Furthermore, the government’s obsession with levels of total cholesterol, which has led to the overmedication of millions of people with statins, has diverted our attention from the more egregious risk factor of atherogenic dyslipidaemia.
Saturated fat has been demonised ever since Ancel Keys’s landmark “seven countries” study in 1970.2 This concluded that a correlation existed between the incidence of coronary heart disease and total cholesterol concentrations, which then correlated with the proportion of energy provided by saturated fat. But correlation is not causation. Nevertheless, we were advised to cut fat intake to 30% of total energy and saturated fat to 10%.”3The aspect of dietary saturated fat that is believed to have the greatest influence on cardiovascular risk is elevated concentrations of low density lipoprotein (LDL) cholesterol. Yet the reduction in LDL cholesterol from reducing saturated fat intake seems to be specific to large, buoyant (type A) LDL particles, when in fact it is the small, dense (type B) particles (responsive to carbohydrate intake) that are implicated in cardiovascular disease.4
Indeed, recent prospective cohort studies have not supported any significant association between saturated fat intake and cardiovascular risk.5 Instead, saturated fat has been found to be protective. The source of the saturated fat may be important. Dairy foods are exemplary providers of vitamins A and D. As well as a link between vitamin D deficiency and a significantly increased risk of cardiovascular mortality, calcium and phosphorus found commonly in dairy foods may have antihypertensive effects that may contribute to inverse associations with cardiovascular risk.6 7 8 One study showed that higher concentrations of plasma trans-palmitoleic acid, a fatty acid mainly found in dairy foods, was associated with higher concentrations of high density lipoprotein, lower concentrations of triglycerides and C reactive protein, reduced insulin resistance, and a lower incidence of diabetes in adults.9 Red meat is another major source of saturated fat. Consumption of processed meats, but not red meat, has been associated with coronary heart disease and diabetes mellitus, which may be explained by nitrates and sodium as preservatives.10
The notoriety of fat is based on its higher energy content per gram in comparison with protein and carbohydrate. However, work by the biochemist Richard Feinman and nuclear physicist Eugene Fine on thermodynamics and the metabolic advantage of different diet compositions showed that the body did not metabolise different macronutrients in the same way.11 Kekwick and Pawan carried out one of the earliest obesity experiments, published in the Lancet in 1956.12 They compared groups consuming diets of 90% fat, 90% protein, and 90% carbohydrate and showed that the greatest weight loss was in the fat consuming group. The authors concluded that the “composition of the diet appeared to outweigh in importance the intake of calories.”
The “calorie is not a calorie” theory has been further substantiated by a recent JAMA study showing that a “low fat” diet resulted in the greatest decrease in energy expenditure, an unhealthy lipid pattern, and increased insulin resistance in comparison with a low carbohydrate and low glycaemic index diet.13 In the past 30 years in the United States the proportion of energy from consumed fat has fallen from 40% to 30% (although absolute fat consumption has remained the same), yet obesity has rocketed.
One reason: when you take the fat out, the food tastes worse. The food industry compensated by replacing saturated fat with added sugar. The scientific evidence is mounting that sugar is a possible independent risk factor for the metabolic syndrome (the cluster of hypertension, dysglycaemia, raised triglycerides, low HDL cholesterol, and increased waist circumference).
In previous generations cardiovascular disease existed largely in isolation. Now two thirds of people admitted to hospital with a diagnosis of acute myocardial infarction really have metabolic syndrome—but 75% of these patients have completely normal total cholesterol concentrations.14 Maybe this is because total cholesterol isn’t really the problem?
The Framingham heart study sanctified total cholesterol as a risk factor for coronary artery disease, making statins the second most prescribed drug in the US and driving a multibillion dollar global industry. In the United Kingdom eight million people take statins regularly, up from five million 10 years ago. With 60 million statin prescriptions a year, it is difficult to demonstrate any additional effect of statins on reduced cardiovascular mortality over the effects of the decline in smoking prevalence and primary angioplasty.15
Despite the common belief that high cholesterol is a significant risk factor for coronary artery disease, several independent population studies in healthy adults have shown that low total cholesterol is associated with cardiovascular and non-cardiac mortality, indicating that high total cholesterol is not a risk factor in a healthy population.16 17 18
A recent “real world” study of 150 000 patients who were taking statins showed “unacceptable” side effects—including myalgia, gastrointestinal upset, sleep and memory disturbance, and erectile dysfunction—in 20% of participants, resulting in discontinuation of the drug.19 This is massively at odds with the major statin trials that report significant side effects of myopathy or muscle pain in only one in 10 000.
A meta-analysis of predominantly industry sponsored data reported that in a low risk group of people aged 60-70 years taking statins the number needed to treat (NNT) to prevent one cardiovascular event in one year was 345.20The strongest evidence base for statins is in secondary prevention, where all patients after a myocardial infarction are prescribed maximum dose treatment irrespective of total cholesterol, because of statins’ anti-inflammatory or pleiotropic (coronary plaque stabilising) effects. In this group the NNT is 83 for mortality over five years. This doesn’t mean that each patient benefits a little but rather that 82 will receive no prognostic benefit.21 The fact that no other cholesterol lowering drug has shown a benefit in terms of mortality supports the hypothesis that the benefits of statins are independent of their effects on cholesterol.
Adopting a Mediterranean diet after a heart attack is almost three times as powerful in reducing mortality as taking a statin. The recently published PREDIMED randomised controlled trial was stopped early after it showed that in high risk people the Mediterranean diet achieved a 30% improvement over a “low fat” diet in terms of cardiovascular events.22
Pharmacotherapy can assuage the symptoms but can’t alter the pathophysiology. Doctors need to embrace prevention as well as treatment. The greatest improvements in morbidity and mortality have been due not to personal responsibility but rather to public health. It is time to bust the myth of the role of saturated fat in heart disease and wind back the harms of dietary advice that has contributed to obesity.
Notes
Cite this as: BMJ 2013;347:f6340
Footnotes
• Competing interests: None declared.
• Provenance and peer review: Commissioned; peer reviewed.
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Micha R, Wallace SK, Mozaffarian D. Red and processed meat consumption and risk of incident coronary heart disease, stroke and diabetes mellitus: a systematic review and meta analysis. Circulation2010;121:2271-83.
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